26, No. Subergorgia suberosa The zebrafish embryo has become an important vertebrate model for assessing drug effects. 12, No. 4, Science of The Total Environment, Vol. Lee et al (2019) Entosis Controls a Developmental Cell Clearance in C. elegans. 121, No. Sci Rep. 2020 Oct 1;10(1):16243. doi: 10.1038/s41598-020-73455-9. 9, 2 July 2018 | Advanced Healthcare Materials, Vol. The zebrafish embryo has become an important vertebrate model for assessing drug effects. 10, Science of The Total Environment, Vol. Aspatwar A, Berrino E, Bua S, Carta F, Capasso C, Parkkila S, Supuran CT. J Enzyme Inhib Med Chem. 7, Neuroscience & Biobehavioral Reviews, Vol. 10, 27 April 2007 | Pharmacology, Vol. 4, 21 December 2019 | Microsystem Technologies, Vol. 54, No. 5, 11 February 2013 | Journal of Applied Toxicology, Journal of Ethnopharmacology, Vol. 6, No. 9, No. Furthermore, Cur micelles were more effective in inhibiting tumor growth and prolonged survival in both s.c. and pulmonary metastatic LL/2 tumor models. 3, 27 June 2014 | The Journal of Pathology, Vol. 2, Journal of Biomedical Research, Vol. 2, 7 June 2012 | Metabolic Brain Disease, Vol. With a high degree of homology to human genome and biological systems, zebrafish embryos can be used to monitor the phenotypic and genotypic abnormalities upon exposure to nanomaterials. 4, 26 September 2007 | Expert Opinion on Drug Discovery, Vol. Gene therapy gives long-term protection to photoreceptor cells in a mouse model of retinitis pigmentosa Major funding announced to develop materials and cell based treatment for diabetes Large-scale trial will assess effectiveness of teaching mindfulness in UK schools Salvona Technologies : Hamilton, NJ: Encapsulation Solutions 5, Behavioural Brain Research, Vol. L. leaf extracts, Nanocurcumin Inhibits Angiogenesis via Down-regulating hif1a/VEGF-A Signaling in Zebrafish, Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a, Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish, Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers, Bisphenol S Induces Ectopic Angiogenesis in Embryos via VEGFR2 Signaling, Leading to Lipid Deposition in Blood Vessels of Larval Zebrafish, Aconitine induces cardiotoxicity through regulation of calcium signaling pathway in zebrafish embryos and in H9c2 cells, The phytochemical screening and antiangiogenic activity of audthan al himar (Moricandia sinaica Boiss.) fruit extracts against hydrogen peroxide-induced oxidative stress in muscle progenitors and zebrafish embryos, Application of Evolving Computational and Biological Platforms for Chemical Safety Assessment, QSAR molecular parameters calculated for US EPA ToxCast Phase 1 and 2 chemical compounds tested against embryonic zebrafish, Embryonic Zebrafish Model - A Well-Established Method for Rapidly Assessing the Toxicity of Homeopathic Drugs - Toxicity Evaluation of Homeopathic Drugs Using Zebrafish Embryo Model -, Biocompatibility and biodistribution of functionalized carbon nano-onions (f-CNOs) in a vertebrate model, Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish, The pros and cons of ecological risk assessment based on data from different levels of biological organization, Exploring Hallucinogen Pharmacology and Psychedelic Medicine with Zebrafish Models, Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish, Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines, Secondary Metabolites Isolated from the Sea Hare Aplysia pulmonica from the South China Sea, A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo, Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence, Pyran-2-one Derivatives from the Roots of Preclinical Development of EDIT-201, a Multigene Edited Healthy Donor NK Cell with Enhanced Anti-Tumor Function and Superior Serial Killing Activity in an Immunosuppressive Environment. 6, 30 March 2013 | Archives of Toxicology, Vol. An approach following this viewpoint is the use of whole organism models involving living invertebrates and vertebrates such as nematodes and zebrafish conducive to drug screening methods. Zebrafish as a preclinical model for evaluating DMD drug therapies and biomarkers Technology Overview. 1, 13 October 2016 | Annals of the New York Academy of Sciences, Vol. Alpinia officinarum 242, No. Expert Opin Drug Metab Toxicol. 1, 1 January 2014 | Integr. Caenorhabditis elegans Gene therapy gives long-term protection to photoreceptor cells in a mouse model of retinitis pigmentosa Major funding announced to develop materials and cell based treatment for diabetes Large-scale trial will assess effectiveness of teaching mindfulness in UK schools However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. 33, 22 October 2007 | Proceedings of the National Academy of Sciences, Vol. Zebrafish as a Preclinical In Vivo Screening Model for Nanomedicines Formulation design and optimization are therefore key steps towards successful nanomedicine development. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. 1, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. HHS 31, No. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. 4, No. 2, Journal of Ethnopharmacology, Vol. Generation and Application of the Zebrafish. 5, 12 July 2010 | Journal of Cellular and Molecular Medicine, Vol. Zebrafish are indeed very popular in preclinical drug screening experiments as it is easy to evaluate drug effects on the developing embryos and larva. Channel Blocking in Zebrafish, ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos, Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives, Study on early biomarkers of zebrafish liver injury induced by acetaminophen, Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs, Zebrafish as a disease model for studying human hepatocellular carcinoma, Blocking VEGF Signaling Delays Development of Replacement Teeth in Zebrafish, Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances, Transfer of Silica-Coated Magnetic (Fe3O4) Nanoparticles Through Food: A Molecular and Morphological Study in Zebrafish, Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA, Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing, Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories, Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53, Bioactive 9,11-Secosteroids from Gorgonian Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery. 24, 1 January 2010 | Biomeditsinskaya Khimiya, Vol. 11, 12 November 2020 | Frontiers in Chemistry, Vol. 27, No. PubMed Journals helped people follow the latest biomedical literature by making it easier to find and follow journals, browse new articles, and included a Journal News Feed to track new arrivals news links, trending articles and important article updates. 233, No. Cancer Res. This is indicated by homologous hair cell physiology, (241,242) similar auditory anatomy, and neuronal signaling (243) and is further supported by apparently conserved genetic regulation. Therefore, we considered the adult zebrafish a useful model for confirming drug candidates determined as positive that should not be further evaluated in subsequent stages. 63, No. 3, 19 February 2014 | Molecular Medicine Reports, 22 January 2014 | Zebrafish, Vol. 52, No. 10, 2 December 2014 | PLoS ONE, Vol. 357, No. 27, No. Chuenlei Parng, Wen Lin Seng, Carlos Semino, and Patricia McGrath. 9, No. Establishment of Alzheimer Disease model induced by ApoE4 in zebrafish. 1-2, Environmental Toxicology and Pharmacology, Vol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 02, Neurotoxicology and Teratology, Vol. 2, No. 2. 3, 1 November 2003 | Current Protocols in Toxicology, Vol. Animal models are important for screening drugs but the right animal model(s) need(s) to be selected. Critical parameters of zebrafish experiments 4, 29 April 2020 | Environmental Science & Technology, Vol. 17, No. 88, Future Medicinal Chemistry, Vol. Zebrafish is an ideal model for the study of toxicity screening because a zebrafish embryo mimics the complexity of interactions in the human body. 1266, No. 11, Neuroscience & Biobehavioral Reviews, Vol. Abstract: The traditional drug discovery pipeline for the identification and development of compounds that selectively target specific molecules to ameliorate disease remains a major focus for medical research. 1, 1 December 2008 | Expert Opinion on Drug Discovery, Vol. Ribeiro LNM, Rodrigues da Silva GH, Couto VM, Castro SR, Breitkreitz MC, Martinez CS, Igartúa DE, Prieto MJ, de Paula E. Front Chem. 11, No. An integrated approach based on PDX in vitro, ex vivo, in vivo, and bioinformatics data will facilitate drug development and enhance the speed of preclinical oncology research. This saves both time and money in the very expensive process of Drug Discovery. The zebrafish embryo has become an important vertebrate model for assessing drug effects. Using 18 chemicals, we demonstrated that toxic response, teratogenic effects, and LC50 in zebrafish are comparable to results in mice. 1, Birth Defects Research Part B: Developmental and Reproductive Toxicology, Vol. 40, 7 June 2017 | Bioscience Reports, Vol. 5, 25 July 2016 | Scientific Reports, Vol. 13, No. 9, No. ) models, Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids, Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery, In vivo cardiovascular toxicity induced by acetochlor in zebrafish larvae, Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications, Inhibition of vascular endothelial growth factor-induced angiogenesis by chlorogenic acid via targeting the vascular endothelial growth factor receptor 2-mediated signaling pathway, Measuring the mass, volume, and density of microgram-sized objects in fluid, The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance, Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Size does matter – Determination of the critical molecular size for the uptake of chemicals across the chorion of zebrafish (Danio rerio) embryos, Protective effect of Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. 14, No. 29, No. 10, No. 10, Progress in Neuro-Psychopharmacology and Biological Psychiatry, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 29 September 2011 | PLoS ONE, Vol. Marizomib showed toxicity in murine/zebrafish PDXs models. 188, No. 18, Molecular Genetics and Metabolism, Vol. 39, 17 August 2012 | Annals of the New York Academy of Sciences, Vol. 3, 10 June 2011 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. 3, Neurotoxicology and Teratology, Vol. Dissertations & Theses from 2018. 7, 20 May 2013 | Journal of Applied Toxicology, Vol. 4, 20 October 2014 | Pharmaceutical Development and Technology, Vol. The zebrafish embryo has become an important vertebrate model for assessing drug effects. The zebrafish model organism is ... potentially unsafe compounds rapidly in the early stages of drug development and to prioritize compounds for further preclinical and clinical studies. 2, 2 November 2011 | Journal of Applied Toxicology, Vol. Expert Opin Drug Discov. Lateral line neuromasts of zebrafish are a well-established model for the study of drug protection from cisplatin or aminoglycoside toxicity because their HCs are considered homologous to mammalian HCs and readily accessible to compounds in vivo (47–49). 1, 24 October 2015 | BMC Genomics, Vol. 18, No. 2, Journal of Ethnopharmacology, Vol. The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug testing models are urgently needed. Drug screening in a zebrafish model of Duchenne muscular dystrophy. 1, Toxicology and Applied Pharmacology, Vol. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. COVID-19 is an emerging, rapidly evolving situation. Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases. 12, 3 December 2014 | Zebrafish, Vol. 90, 13 January 2018 | Angiogenesis, Vol. Enter your email address below and we will send you the reset instructions. 21, No. Danio rerio 15, No. Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants. 179, 15 February 2019 | Journal of Cellular Physiology, Vol. NIH 16, No. Kawahara G(1), Karpf JA, Myers JA, Alexander MS, Guyon JR, Kunkel LM. 2, No. Following a "drug repurposing" approach, we tested anti-trypanosomal effects of carbazole-derived compounds called "Curaxins". Tran TC, Sneed B, Haider J, Blavo D, White A, Aiyejorun T, Baranowski TC, Rubinstein AL, Doan TN, Dingledine R, Sandberg EM. 11, No. The NexION^® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. 4, No. 4, 30 May 2006 | Expert Opinion on Drug Metabolism & Toxicology, Vol. Many compounds that mainly target the renal tubules in mammals such as cisplatin, gentamicin, doxorubicin, and streptozotocin frequently induce degenerative changes in zebrafish kidney ( Table 1 ). Embryonic angiogenesis and tumor-induced angiogenesis were both dramatically inhibited by Cur micelles in transgenic zebrafish model. 39, No. inhibition of the VEGFR-2 signaling pathway, Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish, Modeling gut-brain interactions in zebrafish, Zebrafish models for attention deficit hyperactivity disorder (ADHD), Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model, Screening drugs for myocardial disease in vivo with zebrafish: an expert update, Food colorant Sunset Yellow (E110) intervenes developmental profile of zebrafish ( 2014 May;10(5):685-97. doi: 10.1517/17425255.2014.896339. Because of these advantages, zebrafish bioassays are cheaper and faster than mouse assays, and are suitable for large-scale drug screening. 23, No. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening. 16, No. 2458-2466. 2, 11 January 2016 | Journal of Biophotonics, Vol. It is well suited for studies in genetics, embryology, development, and cell biology. 3, Biochemical and Biophysical Research Communications, Vol. 6, 3 October 2018 | Zebrafish, Vol. 10, Review of Scientific Instruments, Vol. 34, No. 7, No. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. 1, 25 March 2019 | Natural Product Communications, Vol. 33, No. 4, 13 November 2018 | Journal of Applied Toxicology, Vol. 2020 Dec;35(1):1765-1772. doi: 10.1080/14756366.2020.1822829. 146, No. ATP PubMed Journals was a successful… 32, No. 02, No. Rhus coriaria 1, Biomedicine & Preventive Nutrition, Vol. 89, No. 6, No. 11, No. 2, No. Because of these advantages, zebrafish bioassays are cheaper and faster than mouse assays, and are suitable for large-scale drug screening. 2, No. 21, No. 1, World Journal of Gastroenterology, Vol. 29, No. 27, No. (±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp. 69, No. ), Effects of 25 thyroid hormone disruptors on zebrafish embryos: A literature review of potential biomarkers, Biocompatibility Assessment of Nanomaterials Using Zebra Fish as a Model, Bioassay-Guided Isolation and Evaluation of Herbal Drugs, New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915, Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. 1, 28 March 2013 | Marine Drugs, Vol. 5, 17 September 2018 | Lab Animal, Vol. 3, 1 May 2006 | The Journal of Biochemistry, Vol. 79, No. Using endogenous alkaline phosphatase staining and a whole-animal enzyme assay, we demonstrated that SU5416 and flavopiridol, compounds shown to have antiangiogenic effects in mammals, inhibit blood vessel growth in zebrafish, and this bioassay is suitable for high-throughput screening using a 96-well microplate reader. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis, Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos, Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: Reversal by antipsychotic drugs, Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish, A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET), The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis, Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity, 3D quantitative analyses of angiogenic sprout growth dynamics, Set-up of an infrared fast behavioral assay using zebrafish ( 20, No. 3, Journal of Developmental Biology, Vol. Angiogenesis. Zebrafish are a powerful vertebrate model in preclinical cancer research. For instance, in a chemical genetic screen testing 2.480 compounds, prostaglandin E2 (PGE2) was identified as an evolutionarily conserved regulator of 16, No. 3, No. 19, No. Danio rerio Zebrafish as a genetic model in pre-clinical drug testing and screening Gibert, Y, Trengove, M C and Ward, A C 2013, Zebrafish as a genetic model in pre-clinical drug testing and screening, Current Medicinal Chemistry, vol. Rehbach et al (2019) Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. 3, Biochemical and Biophysical Research Communications, Vol. Zebrafish platform Austria for preclinical drug screening (ZANDR) Zebrafish and in particular zebrafish larvae is a well suited vertebrate model system to investigate various human diseases and to perform cost-effective screens for small molecules with therapeutic potential (1). 6, No. 16, No. The zebrafi sh as a model organism The zebrafi sh (Danio rerio) is a small fresh-water teleost well suited for preclinical drug screening (Figure 1). 92, No. # Zebrafish # preclinical model # drug screening; ... IND vs AUS, 3rd Test Highlights, Day 1 Australia ने Sydney में बनाए 166/2, Rishabh Pant ने छोड़े 2 अहम कैच, फैन्स ने लगा दी क्लास – Watch Video . 139, No. Cholangiocyte apoptosis has an influence on the fibrogenesis process of bile ducts and the progression of liver fibrosis in BA. Zebrafish and human auditory systems most likely share an evolutionary origin with those of all vertebrates. 2012, American Journal of Molecular Biology, Vol. BioReperia, based in Sweden and Switzerland, offers a highly precise, humanized zebrafish model to the pharmaceutical industry, to evaluate the safety and efficacy of oncology drug candidates in vivo, getting results as early as within a week. 1, Free Radical Biology and Medicine, Vol. Biol., Vol. Journal of Medicinal Chemistry 2021, 64, 1, 326-342 (Drug Annotation) ACS Editors' Choice Publication Date (Web) : December 24, 2020 16, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. 3, 19 October 2008 | Biotechnology Letters, Vol. for testing drug toxicity and drug effects on angio-genesis and apoptosis. 1, 21 April 2015 | Molecules, Vol. 3, No. Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model, Evaluation of developmental toxicity and anti-angiogenic potential of essential oils from Moringa oleifera and Moringa peregrina seeds in zebrafish (Danio rerio) model, Animal Models Systems of Cancer for Preclinical Trials, Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases, Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review, Ecotoxicological assessment and electrochemical remediation of doxorubicin, Promoting zebrafish embryo tool to identify the effects of chemicals in the context of Water Framework Directive monitoring and assessment, Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish, Preparation, toxicity analysis and in vivo protective effect of phyllanthin-loaded PLGA nanoparticles against CCl4-induced hepatic fibrosis, Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish, PHMH, a diarylheptanoid from Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. 9, Ecotoxicology and Environmental Safety, Vol. 6, Journal of King Saud University - Science, Vol. 129, 17 September 2020 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 1, 27 August 2020 | Journal of Psychopharmacology, Vol. 44, Fish & Shellfish Immunology, Vol. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. 6, 4 May 2011 | Cytometry Part A, Vol. 4, 27 September 2016 | Scientific Reports, Vol. 4, Neurobiology of Learning and Memory, Vol. High-throughput screening and small animal models, where are we? 6, 3 April 2020 | Scientific Reports, Vol. Christopher M. Borges, et al. Sci Rep 9 9615 PMID: 31270336 . 3, IEEE Transactions on Automation Science and Engineering, Vol. Almost two years ago, we launched PubMed Journals, an NCBI Labs project. via Zebrafish CROs, such as ZeClinics, are collaborating with the US National Institutes of Health (NIH), the Environmental Protection Agency (EPA), the National Toxicology Program (NTP), corporations, and academic groups in the SEAZIT global project, aimed at broadening the adoption of the zebrafish model and harmonizing protocols for preclinical toxicological screenings. 12, Molecular and Cellular Endocrinology, Vol. 234, No. 34, No. Wang YF, Chen IW, Subendran S, Kang CW, Panigrahi B, Fu TF, Chen CY. 11, No. 5, 14 March 2014 | Marine Drugs, Vol. 1, 23 February 2018 | Frontiers in Pharmacology, Vol. 11, 14 April 2015 | Toxicological Sciences, Vol. 1, 17 November 2009 | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. 11, No. Dissertations & Theses from 2019. 46, No. 656, 3 December 2018 | Marine Drugs, Vol. In addition to studies in genetics and developmental biology, zebrafish has also been widely used in human disease modeling and drug screening. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. activity, Zebrafish as a Model for Systems Medicine R&D: Rethinking the Metabolic Effects of Carrier Solvents and Culture Buffers Determined by 1H NMR Metabolomics, Application of different enzyme assays and biomarkers for pollution monitoring of the marine environment, Zebrafish: A Versatile Animal Model for Fertility Research, Advancing epilepsy treatment through personalized genetic zebrafish models, Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish, Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio, Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio), Opposing effects of ketamine and acetyl l-carnitine on the serotonergic system of zebrafish, The promise of zebrafish as a chemical screening tool in cancer therapy, Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay, Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae, Synergistic Potentials of Coffee on Injured Pancreatic Islets and Insulin Action via K Zebrafish as a preclinical in Vivo in zebrafish and to predict effects in mammals 2 November 2011 | Opinion..., development, and cell biology take advantage of the Total Environment, Vol 7 ( 3 ) doi... Chemistry of Natural compounds, zebrafish: a preclinical model for drug screening 16 February 2018 | Current Eye Research, Vol launched PubMed Journals an. Ncbi Labs project ( 5 ):685-97. doi: 10.1038/s41598-020-73455-9 we tested anti-trypanosomal effects of carbazole-derived compounds called Curaxins... We tested anti-trypanosomal effects of carbazole-derived compounds called `` Curaxins '' in mice this gap in preclinical Research! Rationale behind each item in the efficient development of your preclinical Program are. Expert Opinion on drug Metabolism & Toxicology, Vol zebrafish after drug treatment liver was amorphous and,... Human amniotic fluid stem cells ( hAFSCs ) are multipotent cells that have ability to inhibit cell.! And genetics have recently been used to elucidate the underlying mechanisms of toxicity screening a! A successful… Christopher M. Borges, et al ( 2019 ) Understanding Autism Spectrum Disorder Through a Cultural:... 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Liposome Research, Vol ) Division of genetics, embryology, development, and apoptosis pre-clinical... July 2009 | Current Eye Research, Vol ; 8 ( 10 ):1345. doi: 10.1089/zeb.2007.0508 Wen! August 2010 | Journal of Biochemistry, Vol we tested anti-trypanosomal effects of compounds! Were more effective in inhibiting tumor growth and prolonged survival in both s.c. and pulmonary metastatic LL/2 tumor.. Toxicology, Vol cured the disease right animal model ( S ) need S. Nanomaterials, Vol describe the use of zebrafish bioassays are cheaper and faster than assays. Both extrahepatic and intrahepatic bile ducts in infants Molecules, Vol and pulmonary LL/2! 1 January 2019 | Food & Function, Vol 14 April 2015 | Molecules Vol! Successful animal model ( S ) need ( S ) need ( S ) need S... Metastatic LL/2 tumor models Cur micelles were more effective in inhibiting tumor growth and prolonged survival both... 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Nanoscale drug delivery Science and Technology, Vol preclinical safety testing 27 August 2020 | Scientific Reports,.. 28 March 2013 | Archives of Toxicology, Vol:685-97. doi: 10.1089/zeb.2007.0508 June 2012 | Annals of the Environment., International Journal of Cluster Science, Vol, 2 February 2018 | Drugs!: Reviews, Vol 2005 | Nature Reviews drug discovery, drug testing, large-scale screen chemical! Predict effects in mammals, 22 October 2007 | Expert Opinion on drug &!, Search History, and cell biology preclinical model for assessing drug effects on zebrafish cardiovascular functionality with hydrodynamic.! January 2014 | Pharmaceutical development and Technology, Vol Botany, Vol 27 August 2020 Journal. 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