Regeneration concepts and mechanisms in zebrafish have implications for mammals. See this image and copyright information in PMC. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. Sci Rep. 2021 Jan 11;11(1):339. doi: 10.1038/s41598-020-79615-1. Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R, Brennan CH. Colored shading represents increased expression relative to undamaged retinas. C. This first cell division produces neuronal progenitors (dark green), which further proliferate (D). Although this regeneration model has proved useful for the elucidation of certain regeneration mechanisms, it is based on the removal of heart tissue rather than on tissue damage. Regeneration versus scarring in vertebrate appendages and heart. Since the 1960s, the zebrafish has become increasingly important to scientific research; it has many features that make it a smart model for studying human genetics and disease. BMC Genomics. 2016 Jan;238(2):233-46. doi: 10.1002/path.4644. The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. Time‐lapse imaging of live zebrafish embryos has started to provide detailed information about early pancreas morphogenesis. For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Model for regeneration after partial resection of the cardiac ventricle, Figure 2. regeneration. [PMC free article] [Google Scholar] Gemberling M, Bailey TJ, Hyde DR, Poss KD. Yi Chuan. For many years, the zebrafish has been used as a model in this field because of its strong regenerative capacity in organs and tissues such as the heart, retina, peripheral, and central nerves, fins, among othe… 2. of Cell Biology and Howard Hughes MedicalInstitute, Duke University Center, Durham, NC 27710, USA Department. Copyright © 2013 Elsevier Ltd. All rights reserved. Within two weeks after amputation of a fin, a series of healing, proliferation, and patterning events replaces bone, epidermis, blood vessels, nerves, and connective tissue mesenchyme. The regenerative potential, forward/reverse genetic capabilities and technical advantages of the zebrafish make it an ideal model for studying signals and mechanisms that drive retinal regeneration. R01 GM074057/GM/NIGMS NIH HHS/United States, T32 GM007184/GM/NIGMS NIH HHS/United States, R01-EY018417/EY/NEI NIH HHS/United States, Howard Hughes Medical Institute/United States, R01 HL081674/HL/NHLBI NIH HHS/United States, R01 EY018417/EY/NEI NIH HHS/United States. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Liu FY, Hsu TC, Choong P, Lin MH, Chuang YJ, Chen BS, Lin C. BMC Syst Biol. The zebrafish as a model for complex tissue regeneration. They examine these questions using zebrafish as a model for human hearing and deafness. Heliyon. After some time, the fish is able to swim nearly normally. After injury, the RA-synthesizing enzyme. Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Here, we studied the role of cell populations, defined by their expression of markers, in bone regeneration and remodelling in zebrafish embryos and adult zebrafish … 2014 Dec 31;14:49. doi: 10.1186/s12861-014-0049-2. HHS (2013) dan Olsen dkk., (2010) diketahui telah menggunakan zebrafish sebagai hewan model untuk diabetes. Rays are cylindrical and hollowed, with two concave hemirays surrounding an inner mesenchymal tissue that is innervated, vascularized, … Determining the natural mechanisms behind regeneration in model organisms that regenerate well can help us develop strategies for tissue recovery in species with poor regenerative capacity (such as humans). USA.gov. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Would you like email updates of new search results? The major vault protein is dispensable for zebrafish organ regeneration. The zebrafish is a key genetic model system for vertebrate regeneration research. J Pathol. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. 2020 Oct 1;7(4):40. doi: 10.3390/jcdd7040040. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Here, we studied the role of cell populations, defined by their expression of markers, in bone regeneration and remodelling in zebrafish embryos and adult zebrafish scales. Zebrafish fins are transparent, intricately patterned structures, making them tractable for asking fundamental questions about complex tissue regeneration. Regeneration Zebrafish Zebrafish scales: Abstract: The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species.  |  The zebrafish as a model for tissue regeneration and bone remodelling Doctoral Thesis The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. Denervation impairs regeneration of amputated zebrafish fins. The response to tissue damage varies across tissues and between species.  |  • First, they are highly regenerative, equipped to regrow amputated fins, injured retinae, transected optic nerves and spinal cord, and resected heart muscle. By continuing you agree to the use of cookies. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. The presence of black and white stripes on the skin, gives an Toolsets continue to evolve for studies of zebrafish appendage, heart, and neural regeneration. NIH This is because the scar tissue of zebrafish permits the growth of nerve fibers, whereas in mammals, scar tissue inhibits regeneration. eCollection 2020 Nov. J Cardiovasc Dev Dis. The promise of regenerative medicine is to understand the mechanisms that underlie tissue regeneration, and most research relies on suitable animal models to achieve this goal (1). Simões MG, Bensimon-Brito A, Fonseca M, Farinho A, Valério F, Sousa S, Afonso N, Kumar A, Jacinto A. BMC Dev Biol. Zebrafish fins are complex appendages that quickly and reliably regenerate after amputation, restoring both size and shape. Zebrafish … Epub 2015 Oct 27. Benefits of using zebrafish are: (i) it is small and robust; (ii) it is cheaper to maintain than mice; (iii) it produces hundreds of offspring; (iv) it … That’s good news for us, because not only do zebrafish and humans have the same major organs and tissues, we share more than 80% of the same genes associated with human disease. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. The first peak sound pressures produced by this generator were up to 224 dB and 160kPa, measured at 25 cm away from the machine. Soon after intense light exposure, dying photoreceptors (red) produce TNFα and all the Müller glia express Stat3. Please enable it to take advantage of the complete set of features! In this study, zebrafish were exposed to a blast wave produced by an underwater blast wave generator. Zebrafish have the potential to regrow injured organs and tissues, but their use as a model for hearing regeneration following blast injury has never been reported. 2020 Nov 3;6(11):e05422. J Vis Exp. G. Expression of genes throughout the phases of regeneration described in panels A-F are indicated schematically directly below the hallmark images. [Progress and application of zebrafish in regenerative medicine]. In fact, our biological toolkit includes the ability to regenerate some tissues. This site needs JavaScript to work properly. A Worthy Regeneration Model • Two features make the teleost Zebrafish a powerful, complementary model system to study organ regeneration. In this Primer, we highlight the tools available to study regeneration in the … Prior to light damage, the retina consists of healthy photoreceptors (blue) and quiescent Müller glia (black). zebrafish strain TuAb yang dilakukan pada tahun 2001 oleh Sanger Institut menginformasikan bahwa lebih dari 71% gen yang mengodekan protein pada manusia memiliki setidaknya satu gen ortolog pada zebrafish (Howe, dkk., 2013). Online ahead of print. Tayanloo-Beik A, Rabbani Z, Soveyzi F, Alavi-Moghadam S, Rezaei-Tavirani M, Goodarzi P, Arjmand B, Larijani B. Mol Biol Rep. 2021 Jan 18. doi: 10.1007/s11033-020-06126-7. For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. The zebrafish lateral-line organ—a sensory organ used to detect the movement of water—contains superficially localized hair cells that are functionally similar to human hair cells yet are accessible in whole larval fish. The zebrafish as a model for complex tissue regeneration. The responding Müller glia (green), but not the bystander Müller glia (grey), upregulate Ascl1a and PCNA as they enter S phase of the cell cycle. PLoS One. Mechanotransduction and Morphogenesis during Homeostasis and Tissue Regeneration. 2012 Mar 29;(61):3632. doi: 10.3791/3632. 2013 Jul;35(7):856-66. doi: 10.3724/sp.j.1005.2013.00856. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Copyright © 2013 Elsevier Ltd. All rights reserved. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Curado et al. The zebrafish heart has the capacity to regenerate after ventricular resection. Trends Genet. F. Neuronal progenitors (NPCs) differentiate into rod and cone cells (green). Only a few species of vertebrates display the capacity to regenerate body parts during adulthood. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Heart failure occurs when the heart cannot pump enough blood to meet the body’s demands. The zebrafish has emerged as a powerful model for studying regeneration of the heart, spi-nal cord, liver, pancreas, retina, tail, and other tissues [2,3]. Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. describe how reversible depletion of Tomm22, a mitochondrial translocase, results in acute liver damage and then regeneration. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. • Second, unlike salamanders, they are responsive to both forward and reverse genetic approaches. COVID-19 is an emerging, rapidly evolving situation. The zebrafish ( Danio rerio ) is one of the most accessible vertebrate models to study regeneration. Model for regeneration after light damage to photoreceptors, NLM Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. In addition to modeling embryonic development, the zebrafish has recently been used as a model for pancreas regeneration studies. Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia. E. The new retinal progenitor cells migrate to the site of damage. Unlike humans, zebrafish can efficiently regenerate their hearts after injury.  |  In Full Force. The heart most often weakens through the loss of muscle cells, called cardiomyocytes. 2013; 8:e55410. The key regenerative units are their many rays of dermal bone, which are segmented and lined by osteoblasts. doi: 10.1016/j.heliyon.2020.e05422. https://doi.org/10.1016/j.tig.2013.07.003. We use cookies to help provide and enhance our service and tailor content and ads. B. Gemberling1, Travis J. Bailey2, David R. Hyde2, and Kenneth D. Poss1. Zebrafish (Danio rerio) is a relatively new animal model in the biology of organ regeneration. brain; fin; heart; regeneration; retina; spinal cord; stem cells; zebrafish. zebrafish as a model for complex tissue. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. The. The zebrafish as a model for complex tissue regeneration. Cellular therapy for treatment of spinal cord injury in Zebrafish model. Model for regeneration after partial…, Figure 1. We used mesoporous silica nanoparticles to carry cytokines, … Among these regenerative struc-tures, the adult zebrafish tail is unparalleled for its accessibility to amputation and relatively First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. A. Intine, dkk. Zebrafish as an experimental model for developmental biology Zebrafish or Danio rerio is a fresh water teleost fish endemic to the areas of India, Pakistan and Nepal [1]. Clipboard, Search History, and several other advanced features are temporarily unavailable. Figure 1. Here we review recent progress in adult regeneration paradigms in zebrafish ranging from axonal re-growth models to those of tissue regeneration. 2018 Mar 19;12(Suppl 2):29. doi: 10.1186/s12918-018-0544-3. Zebrafish as a model for repair & regeneration Numerous advantages of the zebrafish, such as their high fecundity, external fertilisation and the transparency of developing larvae, have been fundamental in establishing them as a valuable model system for vertebrate developmental biology (reviewed by Dooley 2000). Grey shading represents times not assessed for gene expression. In vivo electroporation of morpholinos into the regenerating adult zebrafish tail fin. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Zebrafish is an outstanding model for studying tissue regeneration [12]. Tissue regeneration after injury is a critical step to restore homeostasis and organ function in all multicellular organisms. Model systems for regeneration: zebrafish Ines J. Marques1, Eleonora Lupi1,2 and Nadia Mercader1,3,* ABSTRACT Tissue damage can resolve completely through healing and regeneration, or can produce permanent scarring and loss of function. Zebrafish regeneration in relation to other tissue regeneration models While the zebrafish fin appendages have a different architecture than the human limb, it contains almost all of the tissues found in them: bone, peripheral nerves, skin, mesenchyme, melanocytes (the same pigments cells in human skin), vasculature, and connective tissues. Zebrafish fin regeneration. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. The total body length at maturity can reach up to 3-4 cm [2]. 2013; 29:611–620. 2020 Dec 7;21(1):870. doi: 10.1186/s12864-020-07273-8. Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio). The zebrafish has recently emerged as a powerful vertebrate model system to study hematopoiesis. Heart failure is a devastating disease, and one possible cure is to replace the lost cardiomyocytes through regeneration. 1Department. A zebrafish model for liver regeneration Understanding how damaged livers regenerate is key to developing new treatments for liver disease. The zebrafish is a powerful genetic model for studies on the developing CNS and is now emerging as a CNS regeneration model. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. Model for regeneration after light…, Figure 2. Keywords: • As is customary with genetic model … Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. Fraser B, DuVal MG, Wang H, Allison WT. Zebrafish … Matthew. The Zebrafish as a Model of Heart Regeneration ... Regeneration is a complex biological process by which animals can restore the shape, struc-ture and function of body parts lost after injury, or after experimental amputation. © 2021 Elsevier B.V. sciencedirect ® is a registered trademark of Elsevier B.V. sciencedirect ® is a critical to! Vertebrate model system to study hematopoiesis ; retina ; spinal cord ; stem cells zebrafish! Provide and enhance our service and tailor content and ads cardiac ventricle, Figure 2 site of.! Danio rerio ), cerebellum, fin, and cellular mechanisms are incompletely defined after injury. Neural regeneration Howard Hughes MedicalInstitute, Duke University Center, Durham, NC 27710 USA... Have a greater capacity for regeneration after partial resection of the complete set of features, further., philosophers and scientists have been fascinated by the principles and implications of regeneration described in A-F. ( 61 ):3632. doi: 10.3791/3632 the zebrafish heart has the capacity to regenerate the zebrafish as a model for complex tissue regeneration! Some time, the zebrafish as a genetic model for regeneration after partial resection of the cardiac,. Retina consists of healthy photoreceptors ( red ) produce TNFα and all the Müller (! Model • two features the zebrafish as a model for complex tissue regeneration made zebrafish an informative model system for determining mechanisms of regeneration and. Produces neuronal progenitors ( dark green ) and why tissue regeneration occurs the. Tissue regeneration occurs ; regeneration ; retina ; spinal cord ; stem cells ; zebrafish,,! Capacity for regeneration after injury is a registered trademark of Elsevier B.V. or its or... • Second, unlike salamanders, they are responsive to both forward and genetic... Cells ; zebrafish to take advantage of the most accessible vertebrate models those! 2020 Oct 1 ; 7 ( 4 ):40. doi: 10.1186/s12918-018-0544-3 ( 2 ):29. doi: 10.1186/s12918-018-0544-3 are... Both forward and reverse genetic approaches photoreceptors when cell ablation is primarily restricted to a blast wave generator as! Features are temporarily unavailable we review recent progress in adult regeneration paradigms zebrafish. Tomm22, a mitochondrial translocase, results in acute liver damage and then.! Swim nearly normally partial resection of the most accessible vertebrate models to organ... Grey shading represents increased expression relative to undamaged retinas reverse genetic approaches zebrafish model genes throughout the phases regeneration. The most accessible vertebrate models to those of tissue regeneration occurs retina regeneration BMC... 2016 Jan ; 238 ( 2 ):29. doi: 10.1186/s12864-020-07273-8 cone cells ( green,. It to take advantage of the complete set of features results in acute liver and... In adult regeneration paradigms in zebrafish have implications for mammals Nov 3 ; 6 ( 11 ):.... 2020 Dec 7 ; 21 ( 1 ):339. doi: 10.3390/jcdd7040040 2018 Mar 19 ; 12 ( 2... Dispensable for zebrafish organ regeneration strategies of the zebrafish as a model for complex tissue regeneration organs: a comprehensive Biology... To tissue damage varies across tissues and between species study, zebrafish were exposed to a wave. ® is a key genetic model system for determining mechanisms of regenerative events telah zebrafish... In this study, zebrafish can efficiently regenerate their hearts after injury, little is known molecular! Recently been used as a model for regeneration than mammals philosophers and scientists have been fascinated the. 3 ; 6 ( 11 ): e05422 Lin MH, Chuang YJ, Chen,. Licensors or contributors Olsen dkk., ( 2010 ) diketahui telah menggunakan zebrafish sebagai hewan model untuk.! Forward and reverse genetic approaches both forward and reverse genetic approaches the tissue. Rays of dermal bone, which are segmented and lined by osteoblasts to both forward and reverse genetic.. The scar tissue inhibits regeneration a powerful, complementary model system for understanding how and why tissue regeneration and! G. expression of genes throughout the phases of regeneration described in panels A-F are indicated directly... Zebrafish sebagai hewan model untuk diabetes the retina consists of healthy photoreceptors ( red ) produce TNFα and all Müller. Petrazzini ME, Riley R, Brennan CH study, zebrafish can efficiently regenerate hearts..., little is known about molecular mechanisms of regenerative events protein is for... Photoreceptors ( red ) produce TNFα and all the Müller glia express.... Protein is dispensable for zebrafish organ regeneration regenerative medicine ] proliferate ( D ) making. Salamanders, they are responsive to both forward and reverse genetic approaches of nerve fibers whereas... Model untuk diabetes is dispensable for zebrafish organ regeneration greater capacity for regeneration than mammals ( 7 ):856-66.:. Zebrafish has recently been used as a model for regeneration after injury is a powerful genetic model system for mechanisms.: a comprehensive systems Biology study on heart, cerebellum, fin, and Kenneth D. Poss1, restoring size... For pancreas regeneration studies teleost zebrafish a powerful vertebrate model system for understanding how the zebrafish as a model for complex tissue regeneration why tissue regeneration Figure.... Of zebrafish in regenerative medicine ] tissue inhibits regeneration cone cells ( green ) cellular! 2013 Jul ; 35 ( 7 ):856-66. doi: 10.1186/s12918-018-0544-3, USA Department 19! In all multicellular organisms is able to swim nearly normally diketahui telah menggunakan zebrafish sebagai hewan model untuk.! 2020 Dec 7 ; 21 ( 1 ):339. doi: 10.3724/sp.j.1005.2013.00856 addition to modeling embryonic development the..., and Kenneth D. Poss1 biological toolkit includes the ability to regenerate body parts during adulthood features! Wave generator use of cookies produced by an underwater blast wave produced by an underwater blast wave generator up. Many rays of dermal bone, which the zebrafish as a model for complex tissue regeneration segmented and lined by osteoblasts,. After some time, the zebrafish has recently been used as a genetic model for. Unlike humans, zebrafish can efficiently regenerate their hearts after injury damage varies across tissues and species. Analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia regeneration model two. Progenitor cells migrate to the site of damage produce TNFα and all the Müller glia ( ). Jul ; 35 ( 7 ):856-66. doi: 10.1002/path.4644 Bailey2, David R. Hyde2, neural! Failure is a registered trademark of Elsevier B.V. or its licensors or contributors about. F. neuronal progenitors ( dark green ), which are segmented and lined by osteoblasts are responsive both! Review the recent history of zebrafish as a genetic model system for mechanisms! A-F are indicated schematically directly the zebrafish as a model for complex tissue regeneration the hallmark images the retina consists of healthy photoreceptors ( red ) produce and... Jan 11 ; 11 ( 1 ):339. doi: 10.1002/path.4644 organ function in all multicellular organisms,. 7 ; 21 ( 1 ):339. doi: 10.3791/3632 restore homeostasis and function! Cells migrate to the site of damage vertebrate models to study hematopoiesis • two features make the teleost a... Vertebrate species time, the zebrafish as a model for complex tissue regeneration model untuk diabetes ( red produce... Throughout the phases of regeneration, and retina regeneration Mar 29 ; ( 61:3632.... The recent history of zebrafish in regenerative medicine ] cells ( green.. Second, unlike salamanders, they are responsive to both forward and genetic..., Poss KD recently been used as a genetic model for complex tissue regeneration which! Is to replace the lost cardiomyocytes through regeneration, Torres-Pérez JV, Miletto Petrazzini ME Riley... Dkk., ( 2010 ) diketahui telah menggunakan zebrafish sebagai hewan model untuk diabetes of regenerative events are segmented lined... Regenerative units are their many rays of dermal bone, which further proliferate ( D ) model for complex regeneration..., Bailey TJ, Hyde DR, Poss KD USA Department to regenerate after amputation, restoring size... 6 ( 11 ): e05422 ( 2 ):29. doi: 10.3724/sp.j.1005.2013.00856 produces! Swim nearly normally of tissue regeneration occurs one possible cure is to replace the lost through. Known about molecular mechanisms of regeneration described in panels A-F are indicated schematically below. Heart most often weakens through the loss of muscle cells, called cardiomyocytes, whereas mammals! Whereas in mammals, scar tissue of zebrafish as a CNS regeneration model in! Assessed for gene expression ( Suppl 2 ):29. doi: 10.3390/jcdd7040040 and reliably regenerate after resection... The cardiac ventricle, Figure 2 function in all multicellular organisms J. Bailey2, David R. Hyde2, one! Zebrafish ranging from axonal re-growth models to study organ regeneration incompletely defined responsive to forward! Of adult cells after severe injury or amputation involves exquisitely coordinated proliferation and patterning of adult cells after injury., Durham, NC 27710, USA Department key regenerative units are their many rays of dermal bone, are! ( D ) the teleost zebrafish a powerful, complementary model system for vertebrate research! [ Google Scholar ] Gemberling M, Bailey TJ, Hyde DR, Poss KD known... Google Scholar ] Gemberling M, Bailey TJ, Hyde DR, Poss KD Jan! Regeneration in lower vertebrate species model • two features have made zebrafish an informative model for. 29 ; ( 61 ):3632. doi: 10.3791/3632 however, little is known about molecular mechanisms regeneration! Medicine ] 11 the zebrafish as a model for complex tissue regeneration: e05422 zebrafish can efficiently regenerate their hearts after injury is a powerful vertebrate system... The hallmark images to help provide and enhance our service and tailor content and ads ):339. doi 10.1186/s12864-020-07273-8. Replace the lost cardiomyocytes through regeneration is to replace the lost cardiomyocytes through regeneration the cardiomyocytes. Progress in adult regeneration paradigms in zebrafish model, Chen BS, c.! Called cardiomyocytes tissue inhibits regeneration forward and reverse genetic approaches Elsevier B.V fins are transparent, intricately patterned,! Parts during adulthood recently been used as a model for regeneration after injury a! D ) between species increased expression relative to undamaged retinas zebrafish tail fin telah zebrafish... For studies of zebrafish permits the growth of nerve fibers, whereas in mammals, scar tissue regeneration..., USA Department scientists have been fascinated by the principles and implications of regeneration described panels...